Given that a complex network of co-stimulatory and co-inhibitory molecules regulate T cell immune responses (8), and that differential expression of some of the well characterized molecules (PD-1, CD160, TIM-3, LAG-3, and 2B4) has already been shown to severely affect antigen-specific CD8+ T-cell responses, especially in HIV and HCV (10, 34–36) infections, their expression on iNKT cells of chronic viral diseases are yet to be investigated. Here, CD8A is linked to infection.