IL4 and chronic myelogenous leukemia, BCR-ABL1 positive: It must also be emphasized that the iNKT cells of CML-CP patients have lost their expression of the transcription factor promyelocytic leukemia zinc-finger factor and no longer produce IL-4 during TCR engagement; on the other hand, they show normal expression of IFN-γ in comparison with the iNKT lymphocytes of healthy donors or patients in complete remission following treatment by tyrosine kinase inhibitors such as imatinib mesylate (63).