This finding underscores the possible pathophysiological significance of IL-4 expression by iNKT cells in CML patients; while deficient during the CP, IL-4 expression is restored in remission (63) and could determine the status of innate CD8(+) T cells during the disease or its treatment. The gene discussed is CD8A; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.