At this stage, it would be interesting to determine whether the innate CD8(+) T cells express CXCR3 and CXCR5, two chemokine receptors that were recently described as being associated with CD8(+) T lymphocytes during cancers or chronic viral infection and of which the proliferation is restored following anti-programmed cell death 1 treatment (73). The gene discussed is CD8A; the disease is cancer.