TNF and amyloidosis: While patients with structural mutations usually have a chronic and relapsing course, with an increased risk for developing amyloidosis, and the majority of them also require biologic therapy (mainly IL-1 and TNF blockers) (6, 11), most patients with R92Q-related disease can be treated with NSAIDs or glucocorticoids on demand only (6, 11), and in about 25% of patients (pediatric and adults), symptoms may evolve to spontaneous resolution during the course of the disease, without requiring any treatment (11).