TNFRSF1A and Myalgia: When patients with R92Q-related disease are compared with those carrying structural TNFRSF1A mutations, a family history of an autoinflammatory (R92Q-related) disease and the presence of myalgia, abdominal pain, and ocular symptoms are more frequently observed in the group with structural variants, and pharyngitis/odynophagia and oral aphthosis predominate in patients with R92Q variant (5, 9).