TNFRSF1A and amyloidosis: Compared to patients with TNFRSF1A structural or pathogenic mutations, patients carrying the R92Q variant exhibit milder disease presentation and disease outcome, shorter febrile episodes, lower intensity and frequency of typical symptoms, a considerably lower or inexistent risk for developing amyloidosis, and a later (even during adulthood) disease onset (4, 6, 8, 10, 11, 14).