Compared to healthy controls, levels of CD133 immunoreactivity in CSF revealed no increase in PPMS and myelitis-patients [155% ± 90% (SD) or 59% (SEM); p = 0.768; and 222% ± 134% (SD) or 109% (SEM); p = 0.273, see Figure 4]. This evidence concerns the gene PROM1 and primary progressive multiple sclerosis.