Although a link was detected between miR-214 and the acquired gefitinib resistance in EGFR-mutant NSCLC cell lines via the PTEN/AKT signaling pathway30, the role of miR-214 in the acquired resistance to EGFR-TKIs and the underlying mechanisms have not been fully understood in NSCLC. This evidence concerns the gene EGFR and non-small cell lung carcinoma.