In addition, miR-214 down-regulation was found to confer the resistance to both P-glycoprotein-related and P-glycoprotein-nonrelated drugs in esophageal squamous cell carcinoma45, and this miRNA has been identified as a contributor to the resistance to cisplatin in tongue squamous cell carcinoma lines46. Here, ABCB1 is linked to tongue squamous cell carcinoma.