SIRT3 has been shown to be a negative regulator of cardiac hypertrophy (Sundaresan et al, 2009), ROS production (Qiu et al, 2010), apoptotic cell death (Sundaresan et al, 2008), metabolism (Alfarano et al, 2014), and aging (McDonnell et al, 2015). The gene discussed is SIRT3; the disease is cardiac hypertrophy.