Compared to vehicle‐treated HFD‐fed mice, STA treatment reduced cardiac hypertrophy as shown by the decrease in the LVPWd and IVSTd (Fig 5D and E, respectively), HW/BW ratio (Fig 5F), cardiomyocyte cross‐sectional area (Fig 5G), and myocardial expression of β‐MHC and BNP (Fig 5H and I). Here, NPPB is linked to cardiac hypertrophy.