STUB1 and autosomal recessive spinocerebellar ataxia 16: Our results illustrate that some STUB1 mutations known to cause recessive SCAR16 can affect the protein structure and stability in addition to the ability of CHIP to dimerize in vitro. This provides an alternative mechanism to the previously suggested direct effects on CHIP’s E3 ubiquitin ligase properties and interaction with its chaperones [3].