SREBF1 and Insulin resistance: Although upregulation of SREBP-1c by insulin is unlikely to occur under insulin resistance conditions, SREBP-1c induction by HFD could be accomplished by ER-stress, which, in addition, upregulates the expression of other lipogenic factors including C/EBP and peroxisome proliferator-activated receptor-γ (PPAR-γ) [45].