A probable case is a suspected case with presence of IgM antibody against ZIKV and an epidemiological link; and a confirmed case is a person with laboratory confirmation of recent ZIKV infection: by presence of ZIKV RNA or antigen in serum or other samples or IgM antibody against ZIKV positive and plaque reduction neutralization test ≥ 90% (PRNT90) for ZIKV with titre ≥ 20 and ZIKV PRNT90 titre ratio ≥ 4 compared to other flaviviruses [3]. The gene discussed is CD40LG; the disease is Zika virus infectious disease.