IL18 and Wilson disease: In our study, mice were fed WD for 8 weeks based on our prior study where 4 and 8 weeks of WD induced a significant cardiac dysfunction.1 We cannot exclude that the cardiac dysfunction induced by WD and the protective effects of IL-18 deletion would differ if mice were fed high-saturated fat and high-sugar diet for a longer period, in which metabolic abnormalities will likely become more prominent.