MAGE-C2 enhances TRIM28-induced p53 ubiquitination.9, 36 Oncogenic MAGE-A3/6-TRIM28 ubiquitin ligase inhibits autophagy by causing polyubiquitination and degradation of AMPK in cancer, thereby regulating glucose metabolism in cancerous cells.10, 14 Our findings in this study suggest that decreased expression of FBP1 protein in HCC is mediated, at least partially through oncogenic MAGE-TRIM28 ubiquitin ligase-mediated protein degradation. The gene discussed is FBP1; the disease is hepatocellular carcinoma.