MAGE-A3/6 and MAGE-C2 proteins specifically bind with TRIM28.9, 36 Of note, MAGE-A3 and -C2 proteins are highly expressed in HCC.37, 38, 39 However, the mechanism of action of MAGEs and TRIM28 proteins in HCC tumors is not well understood. The gene discussed is TRIM28; the disease is hepatocellular carcinoma.