TRIM28 also acts as an E3 ubiquitin ligase and forms MAGE-TRIM28 E3 ubiquitin ligase complexes in cancer to target tumor-suppressor proteins such as 5' adenosine monophosphate-activated protein kinase (AMPK) and p53 for ubiquitination and proteasome degradation.9, 10. The gene discussed is TRIM28; the disease is neoplasm.