Dysregulation of miRNAs in cancer has been shown to be associated with epigenetic alterations or transcriptional/post-transcriptional mechanisms.14 Moreover, the expressions of several miRNAs can be regulated by inflammatory stimulus.15 For example, miR155 can be induced by NF-κB in macrophages,16, 17 whereas miR21 is induced by Stat3, a transcription factor activated by IL-6.18 However, it is not well defined how the cross talk between NF-κB and miRNA can modulate all stages from chronic/nonresolving inflammation to initiation and progression of PCa. Here, NFKB1 is linked to posterior cortical atrophy.