Our data showed that miR186 was rapidly induced through the direct binding of activated NF-κB/p65 to the miR186 promoter in P69 and BPH1 cells under inflammatory stimuli (LPS, TNFα), suggesting that miR186 was a new inflammatory response gene except for miR15516 and miR21,18 which are regulated by inflammation signaling, linking inflammation to prostate carcinogenesis. This evidence concerns the gene TNF and medical procedure.