SOD2 and cancer: In addition, 70% of the patients expressed high EGFR levels (P<0.001; Supplementary Figure 4b), and 71% of the patients exhibited MnSOD induction (P<0.001; Supplementary Figure 4c), whereas the majority of cancer patients (92%) had p53 downregulation (P<0.001) (Supplementary Figure 4d).