Surprisingly, we observed that tumor angiogenesis (CD31), cancer-associated fibroblasts (α-SMA) and M2 macrophages (CD163) were all enriched, with increased YY1, p-EGFR (Tyr1068) and MnSOD expression but low p53 expression, in the MCT-1-overexpressing tumors compared with control tumors. This evidence concerns the gene ACTA1 and cancer.