SP1 and neoplasm: MCT-1 enhances EGFR expression, possibly via a cooperative increase in YY1 (Figure 1) and SP1 as previously described.28, 56, 57 MicroRNA-34a (miR-34a) is induced by p53 and directly targets YY1 to inhibit YY1-induced and EGFR-mediated carcinogenesis and metastasis.58, 59, 60, 61 Loss of p53 amplifies MCT-1-YY1-EGFR signaling (Supplementary Figure 1) and induces MnSOD (Figure 4a), which may produce excessive ROS that enhance genetic mutation and tumor progression.