SOD2 and cancer: Upregulation of MnSOD sustains the Warburg effect via mitochondrial ROS generation and AMP-activated kinase activation, which increases the metabolic shift to glycolysis and maintains tumor aggressiveness.15 Targeted suppression of MCT-1, YY1 and EGFR capably effectively suppress MnSOD expression in cancer cells (Figures 4f,5b), emphasizing that the amplification of MnSOD signaling via the MCT-1-YY1-EGFR network may determine cancer cell proliferation, invasion and metastasis.