In mouse embryonic stem cells, zfp281 recruits AFF3 to the Meg3 enhancer within the imprinted Dlk1-Dio3 locus, to regulate the allele-specific expression of the Meg3 polycistron.100 In human colon carcinoma cells, ZNF281 controls epithelial–mesenchymal transition (EMT).95 Indeed, Snail, an EMT-associated protein, promotes the expression of ZNF281 and represses miR-34a/b/c, a target of ZNF281. This evidence concerns the gene MEG3 and colon carcinoma.