In humans, the closest ZNF281 homolog is ZBP-89, which is frequently over-expressed in human cancer cells, where it can efficiently induce apoptosis through p53-dependent and -independent mechanisms.105 A human ZBP-89 splice isoform ZBP-89-DN, which lacks amino terminal residues 1–127 of the full length protein, has also been identified, which predisposes the colon to colitis.106. Here, ZNF148 is linked to cancer.