According to epidemiologic data collected from World Federation of Haemophilia (WFH) and European Network of the Rare Bleeding Disorders (EN-RBD), the prevalence of each deficiency in total affected population is the following: FVII 39%, FXI 26%, fibrinogen, FV and FX 8%–9%, FXIII 6%, combined FV + FVIII 3% and FII 1% [52,53]. Here, F8 is linked to hemophilia.