F8 and von Willebrand disease (hereditary or acquired): In patients with severe forms of VWD, when plasma FVIII level is <5 U/dL, suffering from recurrent joint bleeding or gastrointestinal bleeding, which may also affect patients with type 2 devoid of HMW multimers [18] due to a frequently associated enteric angiodysplasia [46], a secondary long-term prophylaxis may represent an efficacious treatment.