Moreover, Brassicaceae extracts, especially watercress extract, demonstrated also the ability to target the CSC subpopulation and to reduce the ALDH1-mediated chemoresistance of these cells by decreasing the expression of stemness markers (LGR5 and PROM1) and by impairing ALDH1 activity, as well as the ability to target CRC progression by targeting the Wnt/β-catenin/TCF7L2 signaling pathway. This evidence concerns the gene PROM1 and colorectal carcinoma.