In all dengue patients, there were significant negative associations between acute serum HA with serum albumin (Spearman’s rank correlation coefficient (r) = −0.3533, 95% CI −0.5807 to −0.07471, p = 0.0118), total protein (r = −0.3326, 95% CI −0.565 to −0.05138, p = 0.0183) and platelet count (r = −0.5981, 95% CI −0.755 to −0.3764, p < 0.001). This evidence concerns the gene ALB and dengue disease.