ALB and cancer: To investigate our hypothesis, we developed two orthotopic mouse models for breast cancer; a xenograft model using the human MCF10CA1a cancer cell line and a syngeneic model using the mouse 4T1 cancer cell line and employed three commonly used drugs: doxorubicin, which has a size of less than 1 nm; Abraxane, a 130 nm albumin-bound paclitaxel that shrinks to 10 nm following dilution to plasma10; and Doxil, a ~100 nm pegylated liposomal doxorubicin.