In WT mice, HTN was observed with systolic BP of 160 mmHg, diastolic BP of 104 mmHg and mean BP of 126 mmHg measured after 4 weeks of Ang II administration versus values of 120, 85 and 100 mmHg, respectively, in untreated WT mice (Fig. 7a–c). Here, AGT is linked to hypertensive disorder.