High levels of MTA1 (n = 115) and low levels of DNMT3a (n = 124) in colon cancer also results in a decreased probability of disease-specific survival having hazard ratio [95% CI] = 2.16 [1.14–4.11] for MTA1 and hazard ratio [95% CI] = 0.14 [0.03–0.58] for DNMT3a with statistical significance of p = 0.004287 and p = 0.003635, respectively (Fig. 1F). The gene discussed is MTA1; the disease is malignant colon neoplasm.