CNR1 and Anxiety: In the LD test, Stop-CB1 mice (as expected; Jacob et al. 2009; Ruehle et al. 2013) again showed significantly higher anxiety levels than the CB1-RS wildtype-like controls with fewer entries into the light compartment, less time spent in the light compartment, and a longer latency to first enter the light compartment (Fig. 8d–f).