Cholecystokinin has well-known anxiogenic effects, at least in part via the amygdala and prefrontal cortex (Bowers et al. 2012; Li et al. 2013; Vialou et al. 2014), and thus restored CB1 receptor expression in these neurons may reduce anxiety-like behavior via a reduction of cholecystokinin release. Here, CCK is linked to Anxiety.