Eventually, when there is AF, correct OAC treatment is a must as several randomized trials have demonstrated, given that a suboptimal anticoagulation has been associated with poor outcomes in terms of mortality [37] and there is a greatest likelihood of a lower TTR [38] when was associated with heart failure, our results also showed that the survival chance with a diagnosis of CHF was lower (0.69 ± DE 0.09) than when there is no CHF present, but the mean TTR had not different distribution in patients with CHF. This evidence concerns the gene TTR and heart failure.