In this study, we evaluated the status of CDHs in TCGA breast cancer samples, especially in TNBC by using informatics and experimental analyses, and demonstrated that CDH2/4/6/17 themselves and their associated SC-TFs including WWTR1, NFYA, and FOXM1 might be involved in the enrichment of CSCs in TNBC. The gene discussed is CDH2; the disease is breast cancer.