Many studies have demonstrated that S-acylation plays very important roles in the pathogenesis of AD, and the related S-acylated proteins include β- and γ-secretase enzymes, and the major APP (amyloid precursor protein) cleaving enzyme BACE1, which are S-acylated at four sites (Benjannet et al., 2001; Hornemann, 2015). This evidence concerns the gene APP and Alzheimer disease.