APP and Alzheimer disease: In the present study, we have not analyzed the membrane current(s) that may be altered in CA3 hippocampal neurons of young 3xTg-AD mice, however, consistent with the hypothesis of increased neuronal excitability resulting from human APP overexpression, our data indicate that intraneuronal human APP/Aβ leads to network hypersynchronization and ictal-like activity in this AD mouse model.