Bezzina et al. (2015) recently reported the presence of spontaneous epileptiform activity (interictal spikes), increased susceptibility to phenylenetetrazole (PTZ, GABAA receptor antagonist)-induced seizures, and ectopic expression of neuropeptide Y (NPY, marker of epileptic activity) in the mossy fibers of the hippocampus at 1.5 months of age (pre-amyloid plaque and pre-cognitive impairment stage) in Tg2576 mice which harbor hAPPSWE mutation. This evidence concerns the gene NPY and Cognitive impairment.