APP and Alzheimer disease: Interestingly, many AD transgenic mouse models carrying human APP mutation(s) display epileptiform activity and seizure susceptibility prior to amyloid plaque deposition and cognitive impairment (Del Vecchio et al., 2004; Minkeviciene et al., 2009; Westmark et al., 2010; Davis et al., 2014; Bezzina et al., 2015; Duffy et al., 2015).