ASPP2 is a haplo-insufficient tumor suppressor, and can inhibit tumor growth through p53-dependent and -independent pathways in lymphoma, sarcoma, squamous cell carcinoma, and hepatocellular carcinoma (Vives et al., 2006; Kampa et al., 2009; Tordella et al., 2013). The gene discussed is TP53BP2; the disease is squamous cell carcinoma.