Mesalamine, antibiotics, and budesonide are used in patients with mild disease status, while patients with moderately severe IBD take systemic corticosteroids, immune-modulators (thiopurine analogues, azathioprine (AZA), 6-mercaptopurine (6-MP), and methotrexate), and anti-TNFα agents (infliximab, adalimumab, and certolizumab pegol) [13]. Here, TNF is linked to inflammatory bowel disease.