IGFBP2 and neoplasm: Recent research has suggested that the core target genes of miR-126 associated with anti-metastatic activity and tumor-endothelial interactions include a set of eight genes such as c-Mer tyrosine kinase receptor (MERTK), insulin-like growth factor binding protein 2 (IGFBP2) and encoding phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) [26].