In addition, uc001ncr and AX800134 were selected as potential biomarkers in hepatitis B virus (HBV)-positive HCC due to their significantly high-expression in both tissues and serum samples compared with controls, especially in early-stage disease or in patients with alpha-fetoprotein (AFP) ≤ 400 ng/ml [105]. The gene discussed is AFP; the disease is hepatocellular carcinoma.