In addition, the restoration of miR-126-3p expression could be another example of an efficient strategy in HCC treatment, by suppressing angiogenesis and tumor metastasis through low density lipoprotein receptor-related protein 6 (LRP6)) and Phosphoinositide-3-Kinase, Regulatory Subunit 2 (PIK3R2) specific targets. Here, LRP6 is linked to neoplasm.