Furthermore, they found that linkage between syndecan-1, pY576/577-focal adhesion kinase (FAK), pY317-SH2 domain containing transforming protein (SHC) and EGFR, pY1135/1136-insulin-like growth factor (IGF), PI3K/AKT was a prominent feature of STS bone metastasis, while elevated linkage between receptor activator of nuclear factor kappa-B ligand (RANKL) and pT37/46-eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1), EGFR, pY1135/1136- IGF-1 receptor (IGF1R), pY41-Src, pY317-SHC, PI3K p110 gamma (PI3Kp110γ) was associated with short survival. This evidence concerns the gene SHC1 and telomere syndrome.