As a result, four autoantigens, including constitutive photomorphogenesis protein (COP9) signalosome complex subunit 2 (COPS2), cathepsin F (CTSF), 5′-nucleotidase ecto (NT5E), and telomeric repeat binding factor 1 (TERF1), were confirmed as a new panel of biomarkers that could discriminate GC patients from healthy individuals with approximately 95% sensitivity and 92% specificity. Here, NT5E is linked to gastric cancer.