MAPT and frontotemporal dementia: It regulates tau pre-mRNA splicing by suppressing Tau exon 10 inclusion and thus regulating the balance of Tau4R/Tau3R ratio (Ray et al., 2011), associated with tauopathies such as frontotemporal dementia (FTD; Cairns et al., 2007, Connell et al., 2001, Grover et al., 1999, Hasegawa et al., 1998, Hasegawa et al., 1999, Hutton et al., 1998, Mackenzie et al., 2010, Spillantini et al., 1998).