The nucleo-cytoplasmic redistribution of SFPQ under pathological conditions is similar to that reported for the RNA-binding proteins, TDP-43 and FUS, in ALS and FTLD (Neumann et al., 2006, Urwin et al., 2010, Vance et al., 2009). This evidence concerns the gene RBMS3 and amyotrophic lateral sclerosis.