Table 3 contains a list of female breast cancer associated genes and amplified regions that have Mcs3-nominated rat orthologs. Rat Mcs3 was found to contain sequence orthologous to human 11q13/14, which contains multiple genes and is amplified in a subset of female breast carcinomas with poor prognosis (Tsuda et al. 1989). In addition to a functional correlation with breast cancer development, studies reporting genetic associations of CYP2C19 variants with breast cancer susceptibility have been published (Justenhoven et al. 2009; Sangrajrang et al. 2009; Gan et al. 2011). This evidence concerns the gene CYP2C19 and breast carcinoma.