Interestingly, Y-box binding protein 1 (YBX1) has been detected through affinity enrichment combined with sequential window acquisition of all theoretical fragment ions (SWATH)-MS technology and verified by immunoblotting to be a candidate protein interacting with matrix protein, a cleavage product of Gag precursor, in HIV-1 infection [19]. The gene discussed is YBX1; the disease is HIV-1 infection.