RsCC has a higher rate of BRAF mutations and high microsatellite instability (MSI-H), both which have established prognostic importance, with MSI-H tumours shown to have a favourable prognosis, and BRAF a strong poor prognostic marker in non-MSI-H but not in MSI-H tumours [22, 23, 26, 27]. The gene discussed is BRAF; the disease is neoplasm.