PIK3CA and cervical cancer: We tested other recurrent genes in the PI3K, RAS, Apoptosis, and NOTCH pathways, including PIK3CA, ERBB2, NFE2L2, and FBXW7. Interestingly, though these genes were previously reported as pathogenic in cervical cancer, only patients harboring mutant ERBB2 displayed poorer overall survival than those with wild-type (hazard ratio = 0.2864; 95% confidence interval, 0.12 to 0.6836; p value: 0.0027; Fig. 4b).