CASP8 and cervical carcinoma: One recent study of 228 cervical cancers using TCGA data identified SHKBP1, ERBB3, CASP8, HLA-A, and TGFBR2 as novel significantly mutated genes, and previously identified pathogenic genes including PIK3CA, EP300, ARID1A, and NFE2L2 were also confirmed [52].