In order to quantify the proliferative activity of the tumor we used markers associated to cell proliferation and factors related to cell –cycles, such as Ki-67, MCM7 and Cyclin D1, which revealed that the tumor presents a low rate of proliferation (< 5%) in both epithelial and mesenchymal cells (Fig. 2a,b), similar to that reported for other benign odontogenic tumors, such as the odontogenic myxoma (25). The gene discussed is CCND1; the disease is odontogenic neoplasm.