BD is reportedly associated with other ubiquitination-related genes, including ubiquitin associated and SH3 domain containing B (UBASH3B)6, small ubiquitin-like modifier 4 (SUMO4)11–13, and ubiquitin-conjugating enzyme E2Q family-like 1 (UBE2QL1)14, suggesting that the ubiquitination-related pathway may be involved in BD pathophysiology. This evidence concerns the gene SUMO4 and Behcet disease.