Our results revealed that high expression of IMPDH2 could be a prognostic factor for NPC patients with TNM stage I/II (OS: P = 0.012, Fig. 5C; DMFS: P = 0.007, Fig. 5D), TNM stage III/IV (OS: P = 0.028, Fig. 5E; DMFS: P = 0.020, Fig. 5F). This evidence concerns the gene IMPDH2 and nasopharyngeal carcinoma.