Zhang et al. has revealed plasma lipidomic alterations in ovarian cancer in Asian women [48], while Park et al. has validated that LPE, a metabolite of phosphatidylethanolamine (PE), not only increases intracellular Ca2+ via LPA1 and CD97 but also correlates with cell proliferation and migration in breast cancer cells [49]. Here, LPAR1 is linked to breast cancer.