Endosulfan exposure was recently associated to higher risk of prostate cancer incidence in humans probably due to its mutagenic [61], anti-androgen, estrogen agonist and aromatase inducer activites [62]; endosulfan increase activating phosphorylation of EGFR type 2 and it increases activity of several oncogenes like MAPK in prostate cancer cells [63]. This evidence concerns the gene CYP19A1 and prostate carcinoma.