Among factors triggering MS, also prostate cancer treatments could influence its incidence in these patients in fact more than 50% of prostate cancer patients following Androgen Deprivation Therapy (ADT) for more than 6 months develop MS, increases body mass index (BMI), triglycerides and total cholesterol levels, increase LDL/HDL ratio and insulin levels (insulin resistance) with central influence to the all-cause morbidity and mortality in these patients. The gene discussed is INS; the disease is Insulin resistance.