We studied the level of expression of inflammatory chemokines in the blood and bone marrow of patients with MGUS and MM and focussed on chemokines that are major determinants of the migration of the TH1 and TH2 T cell subsets, for which CXCR3 and CCR4 are characteristic and relatively specific markers. This evidence concerns the gene CXCR3 and Miyoshi myopathy.