The Eighth Joint National Committee guideline on management of hypertension recommends a calcium channel blocker or thiazide-type diuretic as initial therapy in the black hypertensive population (whereas an angiotensin-converting enzyme inhibitor, angiotensin receptor blocker, calcium channel blocker, or thiazide-type diuretic is recommended for others with hypertension) [23]. The gene discussed is ACE; the disease is hypertensive disorder.