Similar observations were reported by Gragnani et al. [26] and more extensively by Arcaini et al. [35], who studied 46 HCV-positive patients with indolent NHL treated with IFN-free antiviral regimens and achieved SVR12 in 98% of the patients and lymphoproliferative disease response of splenic marginal zone lymphomas in 73% of the patients. The gene discussed is IFNA1; the disease is splenic marginal zone lymphoma.