While a postnatal HFS diet in lean offspring tended to reduce CX3CR1 expression in the brain (31.6 ± 9.3%, p = 0.055), GDM exposure also tended to reduce CX3CR1 expression in LF-fed offspring (30.6 ± 10.5%, p = 0.057) and an additive effect of GDM exposure and postnatal HFS diet consumption on CX3CR1 expression was observed in the GDM-HFS offspring (54.6 ± 7.3%, p = 0.015) (Fig. 4f, g). The gene discussed is CX3CR1; the disease is gestational diabetes.