EGF and cancer: Type Iγ phosphatidylinositol phosphate kinase (PIPKIγ), upon being phosphorylated by EGF and/or HGF stimulation [5, 6], modulates subcellular production of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) and regulates a variety of cellular processes important for cancer progression, such as cell survival, cell cycle progression, focal adhesion dynamics, vesicular trafficking and actin cytoskeleton reorganization [7–11].