ERBB2 and neoplasm: Gains and focal amplifications affected both mRNA and protein levels significantly (p = 10−16 and p = 10−5, respectively) (Figure 3C and 3D), however, only 34% of the tumors with ERBB2 IHC TCS staining ≥ 2 (Tumor Cell Score, See Materials and Methods) had ERBB2 copy number gains detectable with array-CGH (Figure 3D).