Importantly, high expression of IRF8 was associated with relatively high distant-metastasis-free survival (DMFS) (p = 0.03001) and overall survival (OS) (p = 0.03223) in breast cancers, especially in ER-negative tumors (DMFS, p = 0.00394, OS, p = 0.02847) and grade 3 tumors (DMFS, p = 0.01267, OS, p = 0.00975) (Figure 1E). Here, IRF8 is linked to breast cancer.