ESR1 and breast cancer: To investigate the expression of IRF8 in molecular subtypes of breast cancer, we analyzed expression data for IRF8 in The Cancer Genome Atlas 2012 (TCGA) breast cancer database using the online cBioPortal (http://www.cbioportal.org/) [24, 25], classified according to estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) statuses, mutation and expression of 50 genes (PAM50) (Figure 1A).