CD8A and neoplasm: We hypothesized and confirmed that using a peptide vaccine (Vax) targeting OVA as a model tumor antigen in combination with aGITR/aPD-1 mAb therapy would induce the expansion of cytolytic antigen (Ag)-specific tumor-reactive CD8+ T cells, reduce regulatory T cells, and thus prolong survival in mice with established, palpable B16-OVA tumors.