CLOCK and lung adenocarcinoma: Indeed, using a genetically engineered mouse model of lung adenocarcinoma driven by a mutant version of Kras (KrasG12D) and loss of a tumor suppressor p53, Masri et al. recently showed that the lung adenocarcinoma rewires hepatic circadian rhythm both at the transcriptome level and metabolome level, curiously without affecting the core clock transcription factors for instance Clock [17].