We and others demonstrated that the SINE compound KPT-185 [7] blocks XPO1 function and exerts an anti-lymphoma effect on MCL cells by suppression of oncogenic mediators such as cyclin D1; repression of ribosomal biogenesis, and downregulation of translation/chaperone proteins [5, 8, 9]. This evidence concerns the gene XPO1 and mantle cell lymphoma.