Meta-analysis revealed that HPSE expression was higher in BC tissue than in BCAT (OR = 24.19, 95% CI = 7.84 – 74.61, P < 0.00001; OR = 49.65, 95% CI = 11.77 – 209.46, P < 0.00001; OR = 3.24, 95% CI = 1.53 – 6.85, P = 0.002). The gene discussed is HPSE; the disease is breast cancer.